The current form of high-content screening is based on conventional microscopy. The core technology of HoloMonitor, holographic time-lapse microscopy, creates 3D-movies of unstained living cells that can be computer-processed without requiring the use of toxic labels. This new ability opens the door to more realistic high-content screening of living cells and their behavior over time.
Peter Egelberg, CEO
The progress by Northeastern University and other customers have shown that HoloMonitor technology has the potential to be the non-destructive tool that makes large scale immunotherapies successful and affordable to all patients.
Our participation at the AACR 2015 was further strengthened by three presentations by scientists associated with the Center of Excellence for holographic imaging at Northeastern University in Boston, USA.
When traveling I have the habit of picking up Scientific American, a popular science magazine published by Nature Publishing Group. While casually browsing the first few pages of the February issue, I suddenly froze on page 5. On this page, Hamamatsu Photonics has a full page ad presenting their holographic phase imaging research.
Innovation feeds innovation. Most of PHI’s engineering staff, including myself, spent the greater part of the last decade developing mobile phones for Sony and Ericsson. When introduced to challenges of cell biology research by scientists at Lund University, it became obvious to us that the utilization of consumer electronics would fundamentally transform and progress cell biology research.
This allows HoloMonitor to visualize, track and quantify physical properties of cells over time, without the use of invasive stains. It also allows images to be digitally refocused and assembled into a time-lapse movie containing thousands of cells in each image frame. This enables HoloMonitor to circumvent the deficiencies of conventional time-lapse microscopy and combine the analytical benefits of time-lapse microscopy with flow cytometry in a single revolutionary device for quantitative cell analysis – a time-lapse cytometer.