Use of Wound Healing Assays to Study Cell Migration
Cell migration can be defined as the movement of cells from one location to another in response to biological/chemical signals or environmental events. Migration of cells plays an essential role in many normal biological processes. Therefore, it is not surprising that impaired migration can contribute to pathological conditions in many disease areas like immune responses, tumor metastasis and angiogenesis. Wound healing assays mimic in vivo cell migration. They are in vitro assays widely used in all kinds of research related to directed cell migration.
Gap closure over time. Untreated cells are used and the gap is created using the ibidi® Culture-Insert 2 Well.
Graph showing the direction of cell migration at the left and right edge of the gap, respectively (left). Overlaid cells tracks (right).