PHI - Phase Holographic Imaging » Papers & Posters » Transcription Regulation of Chemokine Receptor CXCR4 by Nuclear Respiratory Factor 1 (NRF1) Controls Estrogen-Induced Malignant Transformation of Breast Epithelial Cells to Breast Cancer Stem Cells

Transcription Regulation of Chemokine Receptor CXCR4 by Nuclear Respiratory Factor 1 (NRF1) Controls Estrogen-Induced Malignant Transformation of Breast Epithelial Cells to Breast Cancer Stem Cells

AACR Annual Meeting , 2016 | J. K. Das and D. Roy
Chemokine receptor CXCR4 is involved in the maintenance of stemness property of stem cells, aging and metastasis of cancer. NRF1 is one of the major transcription factors that controls transcription of CXCR4. In this study, the authors have investigated whether transcription regulation of CXCR4 by NRF1 controls estrogen-induced malignant transformation of breast epithelial cells to breast cancer stem cells.
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