PHI - Phase Holographic Imaging » Articles & Book Chapters » NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression

NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression

Nature Communications, 2017 | J. Ju et al

The authors report that NatD (N-α-acetyltransferase D) promotes the migratory and invasive capabilities of lung cancer cells in vitro and in vivo. On the other hand, depletion of NatD suppresses the epithelial-to-mesenchymal transition (EMT) of lung cancer cells. These findings indicate that NatD is a crucial epigenetic modulator of cell invasion during lung cancer progression.

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