PHI - Phase Holographic Imaging » Articles & Book Chapters » Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells

Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells

Scientific Reports, 2017 | H. Ogawa, M. Koyanagi-Aoi, K. Otani, Y. Zen, Y. Maniwa, T. Aoi

The authors established technologies to generate lung CSC (cancer stem cell) -like cells from human lung cancer cell line A549 by introducing OCT3/4, SOX2 and KLF4, and to construct “lung cancer organoids” in vitro that mimicked human lung cancer tissues. Through the use of these technologies and the evaluation of clinical samples, interleukin-6 was identified as a novel potential therapeutic target for lung cancer stem cells.

Read more
Design by Clavis Communications