Morphology

Morphological Parameters

Kinetic and Multi-parameter Assessment of Cell Morphology

Cell morphology is essential in identifying the shape, structure, form, and size of cells and provides key information about cell health. Together with cell proliferation, i.e. cell count and confluence, morphological parameters are also useful in toxicity analyses. HoloMonitor® is designed to monitor changes in cell morphology over time. The analysis includes data for both individual cells and entire populations at the same time, allowing for non-invasive, fast and reliable toxicity studies.

Some of the morphological parameters that can be analyzed using HoloMonitor.

HoloMonitor® Kinetic Morphology Assessment - A Multi Parameter Toolbox

A vast line of morphological parameters can be determined over time using HoloMonitor. Changes in morphological parameters precede dramatic cellular events like mitosis and cell death, and therefore used as early and sensitive markers for detection of various drug effects and mode of actions. As all HoloMonitor applications morphology assessment is cell-friendly and analysed without the use of any labels or stains. Morphological parameters are, for example, useful

  • For evaluation of cell culture health and QC
  • As early and sensitive markers to detect  drug effects
  • To provide information on drug mode of action
  • For identification of dying cells

Morphology assessment can be used stand alone or in combination with other applications as cell proliferation, cell motility and migration and cell cycle monitoring.

The shape of cells changes continuously as cells move and divide. Using the HoloMonitor, these changes can be monitored and quantified.

Products

  • PHI HoloMonitor M4 with Hstudio software
  • Culture vessel and PHI vessel holder for selected vessel
  • PHI HoloLid for selected vessel